I recently watched Kyle XY on Disney+. I don’t think any of the actors in that did much noteworthy after. The actress that played Jessie is Lady Sif in the Thor movies. The guy who played Josh was in a short lived medical sitcom called Carol’s Second Act, which is funny because there was an episode where Josh said he wanted to be a doctor.

Anyway, I find when the majority of the cast aren’t really known for anything else, it gives the show more of an air of mystique, like it almost comes from another world